In 1892 the campus was expanded and renamed the Asheville Normal and Collegiate Institute, with the goals of providing higher education for young women from the southern Appalachians and of training teachers, particularly for rural schools. Thomas Lawrence was the first principal of the normal school and served in that role until 1907. Pease House opened on the campus in 1908 to serve as a home for girls under the age of 12 "who cannot be trained in homes of their own"; the girls were taught by seniors from the normal school. Pease House operated until 1925.
Edward R. Childs directed the school from 1907 to 1916, when John E. Calfee took over and presided over a period of rapid institutional growth. In 1921 the Asheville Normal and Associated Schools consolidated the Presbyterian missionary schools in the area; it included Asheville Normal, Home School, and Pease House on the central campus in Asheville and the Farm School for boys in Swannanoa. By 1926 the school had evolved from a two-year normal school into a four-year teachers college. In 1931 the name was changed to Asheville Normal and Teachers College.
In 1940 the Presbyterian Board of Missions withdrew its support of the college. The Asheville community attempted unsuccessfully to take on the financial burden of operating the school. Asheville College, as it had been renamed, closed at the end of the term in 1944. The campus was taken over for use by Memorial Mission Hospital, and school records were transferred to the Farm School (now Warren Wilson College).