Oconostota (Great Warrior), who had been a recent delegation hostage, led an attack on the fort to obtain the release of the Cherokees. The commander of the fort was killed, leading the soldiers to massacre the hostages. Col. Archibald Montgomery subsequently led 1,600 men in an attack on the Cherokees. After relieving Fort Prince George, Montgomery marched toward the Cherokee Middle Towns in western North Carolina.
On 27 June 1760, about eight miles south of Etchoe (near the present-day town of Otto at the deserted Cherokee town of Tessante Old Town), the first Battle of Etchoe took place. Oconostota ambushed Montgomery, killing 20 of his men and wounding 70, including Montgomery himself. Montgomery returned to Charles Towne to begin a new assignment, but meanwhile the Cherokees captured Fort Loudoun in present-day Tennessee. In response, Col. James Grant, a member of Montgomery's earlier expedition, led 2,400 men in a decisive blow against the Indians.
On 10 June 1761, about two miles south of Tessante Old Town and the site of the earlier battle, a second Battle of Etchoe took place. After nearly six hours of fighting, the Cherokees retreated and Grant went on to attack the Middle Towns, which had never been invaded before. Grant's expedition destroyed 15 towns and 15,000 acres of crops and drove 5,000 Cherokees into the remote mountains. Peace was signed with the Cherokees in September 1761.