Governor George Yeardley of Virginia first mentioned the Eno Indians (whom he called Haynokes) in connection with their resistance to Spanish explorers. In 1670 John Lederer, a German explorer, gave a somewhat detailed description of the tribe he called the Oenock Indians, who commonly hired themselves out as porters and carriers to neighboring tribes. A few years later, traders' accounts located Aeno- or Eno-Town as a two-days' journey from the Occaneechi village (then located on the Roanoke River) and close to the Great Trading Path that ran roughly from present-day Petersburg, Va., to the Catawba Indian communities in South Carolina.
John Lawson, surveyor general of the colony of Carolina, tells of meeting with Eno-Will, a leader of the Eno Indians and related tribes, in his 1701 exploration. He was entertained at Occaneechi, then located on the Eno River near Hillsborough, and Adshusheer, a combined Eno, Shakori, and Adshusheer village 14 miles east of Occaneechi. Lawson's is the only extended description of the culture of these related tribes.
The combined tribes at Adshusheer suggest the decline in numbers that the individual tribes had already suffered. In 1716 Governor Alexander Spotswood of Virginia tried to settle their remnant permanently at Eno-Town to act as protection from more hostile tribes, but the governors of North Carolina and South Carolina opposed the plan. From this time on, the Eno tribe disappears from the historical record. They were possibly incorporated into the Catawba Nation. William Byrd's history of the survey of the dividing line between Virginia and North Carolina in 1729 presents an elderly, demoralized Shacco-Will, who is almost unrecognizable as Lawson's earlier dignified, respected, and responsible Eno-Will.